"Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium in Multiphoton Microscopy." Nano Lett 17, no. 3 (Mar 08

This class of stimuli-responsive nanoparticles is inactive during blood circulation and under normal physiological conditions, but is activated by acidic pH, enzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment.

The STIRENA project focused on the development of novel stimuli-responsive nanoparticles for potential applications as drug delivery By integrating inorganic NPs such as gold NPs, quantum dots, and iron oxide nanoparticles with fDNA, we designed stimuli-responsive fDNA–NPs that exhibit target induced assembly and disassembly of NPs, resulting in a variety of colorimetric, fluorescent, and magnetic resonance imaging (MRI)-based sensors for diagnostic of a broad range of analytes. responsive nanoparticles. 4. Gases.

ABSTRACT Nanotechnology has become an outgrowing field in novel drug delivery system. It confers several merits over conventional formulations like increased solubility and bioavailability, targeted drug delivery and a decreased dose of the 2019-09-21 Against this backdrop, stimuli-responsive antibiotic-loaded nanoparticles and materials with antimicrobial properties (nanoantibiotics) present the ability to enhance therapeutic efficacy, while also reducing drug resistance and side effects. 2018-02-13 2019-01-10 Adapted with permission from ref. 30 (copyright 2015, American Chemical Society). (e) Reversible self-assembly of NPs controlled by a photoacid. Adapted with permission from ref.

Stimuli-responsive self-assembly of nanoparticles 1. Solvents. Depending mostly on the ligand molecules bound to their surfaces, nanoparticles exhibit good solubility in 2. Acid/base. It has long been recognized that the colloidal stability of nanoparticles is largely dependent on the NP 3.

Special attention is paid to the design and nanoparticle formulation of these so‐called smart drug‐delivery systems. Dual stimuli‐responsive nanoparticles capable of fine‐tuning drug release to augment therapeutic efficacy have become a promising tool for anticancer drug delivery.

2013-10-23 · Nanoscale materials that deliver drugs in response to specific stimuli offer enhanced control of the drugs' release profile and distribution. This Review provides a comprehensive discussion of

These nanoparticles either response to internal stimuli such as Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn 2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided. In order to reconcile the conflicting needs for extended circulation time, extensive tumor tissue penetration, and enhanced cellular uptake for nanodrug delivery systems, we designed DOX-containing hypersensitive nanoparticles that responded to the tumor microenvironment for programmed DOX delivery. In one example, the multiple stimuli- responsive nanocarriers could be discharged into small nanoparticles by responding to the low pH in tumor microenvironment, and then the platinum prodrugs in the small nanoparticles were activated by GSH for promoted penetrating and treating the poorly permeable pancreatic tumors . Polypeptide nanoparticles composed of thiol-modified polylysine (PLL) are cross-linked with disulfide bonds and modified with poly (ethylene glycol) (PEG) and pH-sheddable dimethylmaleic anhydride (DMMA), which exhibit reduction- and pH-responsiveness.

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy.
Copenhagen university jobs

Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium in Multiphoton Microscopy.
H&m falun nummer

Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Folding driven self-assembly of a stimuli-responsive peptide-hyaluronan

Inorganic and organic polymer-grafted nanoparticles : their nanocomposites and characterization. W. Zhao et al., "In Situ Cross-Linking of Stimuli-Responsive "Combination of silica nanoparticles with hydroxyapatite reinforces poly (L-lactide In his thesis, Daniel Klinger highlights the approach of stimuli-responsive microgels for such applications and discusses why especially light as a trigger has an av L Carlsson · 2014 · Citerat av 55 — The nanoparticles were found to increase in size with increasing molar mass of properties such as hydrophobicity or responsiveness to external stimuli.

Stimuli responsive nanoparticles systems are divided into 2 classes: internal (pH, enzyme, ROS, hypoxia, redox) and external (radiation, electromagnetic, thermal) stimuli depending upon the method of inducing the delivery of the drug (Figure 1) (Taghizadeh et al., 2015; Yao et al., 2016).

This thesis mainly focuses on the development of stimuli responsive nanoparticles for cancer targeted therapy. These nanoparticles either response to internal stimuli such as Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn 2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided. The stimuli-responsive nanocarriers are mainly functionalized to delivery, release and activate cargos in specific regions (e.g., tumor microenvironments or intracellular spaces of cancer cells) by responding to internal/external stimuli, e.g., pH, enzymes, etc. [ 18, 19 ], while the ligand-installed nanocarriers are mainly applied to promote the specific internalization between nanocarriers and specific cells, e.g., … Using stimuli responsive core-shell particles to produce responsive colloidosomes from emulsion templates 73. Amihay Freeman (Tel Aviv University) Silver-coated biologically active protein hybrids: Biomedical applications 74. Rahul Jayant (Institut Charles Sadron) Spray mixing - A new approach toward the preparation of plasmid DNA complexes 75.

Stimuli-Responsive Nanoparticles for Targeting the Tumor Microenvironment Jinzhi Du1, Lucas A. Lane1, and Shuming Nie1,2 1Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322; snie@emory.edu 2College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu Province Dual-Stimuli-Responsive Polypeptide Nanoparticles for Photothermal and Photodynamic Therapy Peiyu Zhang Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China 2013-05-01 Herein the state of the art of stimuli‐responsive polymeric nanoparticles are reviewed. Such systems are able to control drug release by reacting to naturally occurring or external applied stimuli.